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Additional resistance routes involve elevated DNA repair capacity via nucleotide excision and mismatch repair pathways, aberrant DNA methylation, altered membrane trafficking due to cytoskeletal disorganization, overexpression of molecular chaperones, dysregulated expression of microRNAs, and changes in transcription factors or small GTPases [107]

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discard any vial that appears cloudy, discolored, or contains visible particles, and never use a product that is past its stability window